Author Archives: thewellbio

ARMI BioFabUSA Fall Summit 2019

It was a pleasure meeting all the great pioneers at ARMI BioFabUSA Fall Summit 2019 conference.  We look forward to connecting and collaborating with various companies that attended to bring large-scale manufacturing of engineered tissues and tissue-related technologies practical for existing industries.  Looking forward to the next summit meeting in Spring 2020!  

B49 and the B(ea)ST: A novel BST-based analog, B49, may prevent breast cancer metastasis by disrupting BST-2 dimerization

Three-dimensional hydrogels help to unravel the role and mechanism of action of BST-2 in breast cancer growth and metastasis and introduce a putative new therapy Institution: Carver College of Medicine, University of Iowa, Stony Brook University, Stanford University School of Medicine Team: Wadi D.  Mahauad-Fernandez, Chioma M.  Okeoma * Application: 3D tissue model to evaluate […]

Breaking the (cell) cycle: Introducing CDK9 as a prognostic biomarker and therapeutic target in synovial sarcomas

Repressing CDK9 blocks cell spheroid formation in 3D culture and delays growth of synovial sarcoma cells Institution: Carver College of Medicine, University of Iowa, Stony Brook University, Stanford University School of Medicine, Atta-ur-Rahman School of Applied Bio sciences, National University of Sciences and Technology Team: Wadi D.  Mahauad-Fernandez, Wasifa Naushad, Tyler D.  Panzner, Amani Bashir, […]

Getting to the root of the problem: Injectable VitroGel® 3D hydrogel scaffolds enhance odontogenic differentiation in vivo

The biocompatible and injectable VitroGel hydrogel culture system enhances pulp-dentin regeneration and has the potential for chair-side regenerative endodontic procedures Institution: The Fourth Military Medical University, China Medical University Team: Min Xiao, Jun Qiu, Rong Kuang, Beidi Zhang, Wei Wang*, Qing Yu * Application: In vivo utilization to study biocompatibility and differentiation potential of primary […]

Trk-ing down castration-resistant prostate cancer: 3D organoid models reveal a new drug target for an aggressive form of prostate cancer.

Three-dimensional cancer-derived organoids introduce TrkA as a promising new biomarker and target for a nearly incurable disease. Institution: University of Campania Team: Marzia Di Donato, Gustavo Cernera, Antimo Migliaccio*and Gabriella Castoria * Application: 3D tissue model to evaluate role of a gene in tumor progression Disease model: Prostate cancer Cell types: Human PC-derived DU145 cells […]

3D Cell Culture of Glioblastoma Cell (U-87 MG) in VitroGel® Hydrogel System

Application Note TheWell Bioscience Inc. Introduction Glioblastoma is an aggressive type of cancer that occurs in the brain or spinal cord. Over the years, various models of glioblastoma have been developed to help understand the mechanism initiation and progression1,2. However, this has been complicated by the diverse and complex genetic and environmental factors that promote […]