Author Archives: thewellbio

VitroGel’s ability to enhance the ECM-cell interaction enhances transplantable capacity of MSCs in rat models of intervertebral disc regeneration

VitroGel® RGD enhances stem cell transplantation to treat intervertebral disc degeneration using rat models, laying new foundations in the movement toward cell-based tissue therapies. Institution: Dalian Medical University, Clinical Medical College of Yangzhou University Team: Feng Wang, Li-ping Nan, Shi-feng Zhou, Yang Liu, Ze-yu Wang, Jing-cheng Wang, Xin-min Feng *, and Liang Zhang Application: 3D […]

Defrosting Fertility: VitroGel offers a viable alternative to ovarian tissue cryopreservation

In vitro three-dimensional culture of murine ovarian follicles in the VitroGel demonstrates superior morphology and growth compared to other biomaterials and 2D culture. Institution: Seoul National University, Eulji University Team: Eun Jung Kim, Chungmo Yang, Jaewang Lee, Hye Won Youm, Jung Ryeol Lee *, Chang Suk Suh, Seok Hyun Kim Application: 3D follicle culture Disease […]

One step closer: ADK-L as a potential therapeutic target for aggressive metastatic breast cancer

Manipulation of the adenosine metabolite ADK-L may offer a way to modulate cell invasion and proliferation of breast cancer cells, offering a possible therapeutic solution to aggressive breast cancers. Institution: Legacy Research Institute, Mid-Columbia Medical Center Team: Bahar Shamloo*, Nandita Kumar, Randall H. Owen, Jesica Reemmer, John Ost, R. Serene Perkins, and Hai-Ying Shen* Application: […]

ARMI Member Spotlight

We are excited to be a part of the ARMI BioFabUSA program. We look forward to the collaborations to help ARMI’s mission to make practical the large-scale manufacturing of engineered tissues and tissue-related technologies, to benefit existing industries and grow new ones. “TheWell Bioscience Inc., a New Jersey biotech company focused on 3D cell culture, […]

TheWell Bioscience Launches A New Generation of Bioinks for 3D Bioprinting

North Brunswick, NJ., January 16, 2020 – TheWell Bioscience Inc, a biotech company focusing on 3D cell culture, launches VitroINK™, a new series of xeno-free tunable bioink system that requires no UV, no temperature/pH curing or chemical crosslinking. The new bioinks are ready-to-use at room temperature, have excellent visibility after printing, and can incorporate multiple […]

Breakdown in Communication: Extracellular Vesicles Drive Lung Cancer Progression by Shuttling c-Myc

Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Institution: Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto di scienze e tecnologie Molecolari CNR Team: Cristina Borzi, Linda Calzolari, Anna M. Ferretti, Laura Caleca, Ugo Pastorino, […]

OSA 1777: A New Tool in the Fight Against Bone Cancer

Introducing OSA 1777, a cell line derived from recurring osteosarcoma, which unlike existing cell lines, forms spheroids in 3D culture reminiscent of osteosarcoma tumors. Institution: David Geffen School of Medicine, University of California, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Chinese Academy of Medical Sciences and Peking Union Medical College Team: Pichaya […]

A New Weapon Against an Old Foe: PPM1D Inhibitors Are a Promising New Treatment for a Deadly Childhood Brain Tumor

New mechanistic insights into the tumorigenesis of DIPG yield a novel potential treatment: PPM1D inhibitors Institution: Emory School of Medicine Team: Mwangala Precious Akamandisa, Kai Nie, Rita Nahta, Dolores Hambardzumyan, and Robert Craig Castellino * Application: Use of VitroGel 3D for in vivo studies and assessing cell survival Disease model: Diffuse intrinsic pontine glioma (DIPG) […]