Category Archives: Research Highlights

Long-Lived Lab Grown Cells for Diabetes Treatment

3D-hydrogel long-term cultured human islets showed maintenance of mass, viability, and function.

Institutions:City of Hope National Medical Center, CA Team:Omori, K., Qi, M., Salgado, M., et al., and Kandeel, F. Disease Model:Diabetes & Kidney Transplantation Hydrogel:VitroGel® 3D Human islet beta cells can be grown in 3D cell culture for up to eight weeks, rather than the three days they would survive in standard 2D culture. These cells […]

Bringing a Small Intestine Model into the Laboratory

Vitrogel increased cell proliferation by a factor of 1.70 compared to a cell control.

Institutions:University of Graz, Austria Team:Zeiringer, S., Wiltschko, L., Glader, C., Reiser, M., Absenger-Novak, M., Frölich, E., & Roblegg, E. Disease Model:Intestinal Absorption Hydrogel:VitroGel® Hydrogel Matrix Three hydrogels were tested as possible extracellular matrix mimics to establish a viable model of the human small intestine in the lab. The extracellular matrix, or ECM, is a network […]

Bulking up Stem Cells to Get into the Healing Game

MSC expansion in vertical-wheel bioreactors utilizing a fed-batch process while utilizing VitroGel

Institutions:Rutgers University Team:Teryek, M., Jadhav, P., Bento, R., and Parekkadan, B. Disease Model:Liver & Kidney Failure Hydrogel:VitroGel® MSC Mesenchymal stem cells (MSCs) can be grown up to scale and genetically tuned for therapeutic deployment using a combination of a xeno-free hydrogel system and a vertical wheel bioreactor. In recent years we have been able to […]

Finding Living Needles in a 3D Haystack

Experimental setup for optical coherence tomography (OCT) imaging with cells encapsulated in VitroGel 3D

Institutions:National Institute of Standards and Technology (NIST) and National Institutes of Health (NIH), Maryland, USA Team:Babakhanova, G., Agrawal, A., Arora, D., Horenberg, A., Budhathoki, J.B., Dunkers, J.P., Chalfoun, J., Bajcsy, P., & Simon Jr., C.G. Disease Model:Tissue Repair Hydrogel:VitroGel® 3D The use of 3D optical coherence tomography (OCT) proves to be a quick, easy, and […]

An Artificial Womb for the Womb

Images on oocyte maturation of the follicles in different culture systems using VitroGel 3D, RGD, and IYR

Institutions:Shengjing Hospital of China Medical University & University of British Columbia Team:Zhao, X., Zhang, S., Gao, S., Chang, H.-M., Leung, P.C.K., and Tan, J. Disease Model:Ovarian Cancer Hydrogel:VitroGel® RGD Three-dimensional cell culture in a hydrogel that was augmented with laminin peptides supports follicle tissue maintenance and hormonal function ex vivo. The human ovary contains an […]

Taking Away a Notch in the Belt of Pancreatic Cancer

kruppel-like-factor-notch-signaling-pancreatic-adenocarcinoma-vitrogel

Institutions:Taipei Medical University, National Cheng Kung University, National Sun Yat-Sen University, and the National Institute of Cancer Research, Taiwan, and the Mayo Clinic. Team:Tsai, Y.-C., Cheng, K.H., Jiang, S.S., Hawse, J.R., Chuang, S.E., Chen, S.L., Huang, T.-S., and Ch’ang, H.-J. Disease Model:Pancreatic Cancer Hydrogel:VitroGel® Hydrogel Matrix A mouse model for pancreatic cancer is developed that […]

Cutting Colon Cancer Out Properly

Blot analysis of EMT markers and NY-YA isoforms in CRC cell lines and optical microscopy images of Empty, NF-YAs and NF-YAI 3D colonies morphology in Vitrogel matrix

Institutions:University of Modena and Reggio Emilia, University of Milan, Italy Team:Rigillo, G., Belluti, S., Campani, V., Ragazzini, G., Ronzio, M., Miserocchi, G., Bighi, B., Cuoghi, L., Mularoni, V., Zappavigna, V., Dolfini, D., Mercatali, L., Alessandrini, A., and Imbriano, C. Disease Model:Colon Cancer Hydrogel:VitroGel® 3D A protein that binds DNA and can trigger colorectal cancer apparently […]

No Relaxing in the Fight Against Liver Cancer

VitroGel matrix stiffness regulates the cancer stem‑like cell phenotype in hepatocellular carcinoma

Institutions:Lanzhou University, China Team:Wei, J., Yao, J., Yang, C., Mao, Y., Zhu, D., Xie, Y., Liu, P., Yan, M., Ren, L., Lin, Y., Zheng, Q., & Li., X. Disease Model:Liver Cancer Hydrogel:VitroGel® 3D Cancer cell stiffness was measured by atomic force microscopy in tumors taken from liver cancer patients. The findings suggest that there are […]

Cooking Up Capillaries – Organ-On-A-Chip with HUVECs

Institutions: National Chung Hsing University, Taiwan Team: Lin, Y.-T., Tung Y.-T., Wong, J.-Y., and Wang, G.-J. Disease Model: Microvascular System Biomimetics Hydrogel: VitroGel® RGD Researchers find a facile way to create synthetic microscopic vessels in the laboratory utilizing VitroGel RGD. Biomimetics is the study of how we can create nature-inspired materials for human use. One […]