Scientists from Florida A&M University have discovered the ability of Tel and DXTPL combination system to increase the power of DXTPL to penetrate cancer stem cells and decrease the chances of cancer relapse and metastasis. Institution: Florida A&M University Team: Peggy Arthur, Nilkumar Patel, Sunil Kumar Surapaneni, Arindam Mondal, Aragaw Gebeyehu, Arvind Bagde, Shallu Kutlehria, […]
In vitro three-dimensional culture helps to demonstrate that several pseudogenes, including HMGA1P6, are involved in metastasis of ovarian cancer, introducing another unconventional target for cancer therapeutics. Institution: Shandong University Team: Xiaoxue Tian, Jianping Song, Xiyu Zhang, Mingyao Yan, Shourong Wang, Yuqiong Wang, Limei Xu, Ling Zhao, Jian-jun Wei, Changshun Shao, Beihua Kong *, and Zhaojian […]
Maternally derived adipose stem cells have emerged as a possible solution to the common immunological rejection observed in fetal repair surgeries. Institution: Showa University School of Medicine Team: Akihiro Kawashima*, Rika Yasuhara, Ryosuke Akino, Kenji Mishima, Michiko Nasu, Akihiko Sekizawa Application: In vivo utilization of VitroGel RGD to study neuronal differentiation capacity Disease model: Neurometabolic […]
VitroGel® RGD enhances stem cell transplantation to treat intervertebral disc degeneration using rat models, laying new foundations in the movement toward cell-based tissue therapies. Institution: Dalian Medical University, Clinical Medical College of Yangzhou University Team: Feng Wang, Li-ping Nan, Shi-feng Zhou, Yang Liu, Ze-yu Wang, Jing-cheng Wang, Xin-min Feng *, and Liang Zhang Application: 3D […]
In vitro three-dimensional culture of murine ovarian follicles in the VitroGel demonstrates superior morphology and growth compared to other biomaterials and 2D culture. Institution: Seoul National University, Eulji University Team: Eun Jung Kim, Chungmo Yang, Jaewang Lee, Hye Won Youm, Jung Ryeol Lee *, Chang Suk Suh, Seok Hyun Kim Application: 3D follicle culture Disease […]
Manipulation of the adenosine metabolite ADK-L may offer a way to modulate cell invasion and proliferation of breast cancer cells, offering a possible therapeutic solution to aggressive breast cancers. Institution: Legacy Research Institute, Mid-Columbia Medical Center Team: Bahar Shamloo*, Nandita Kumar, Randall H. Owen, Jesica Reemmer, John Ost, R. Serene Perkins, and Hai-Ying Shen* Application: […]
Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Institution: Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto di scienze e tecnologie Molecolari CNR Team: Cristina Borzi, Linda Calzolari, Anna M. Ferretti, Laura Caleca, Ugo Pastorino, […]
Introducing OSA 1777, a cell line derived from recurring osteosarcoma, which unlike existing cell lines, forms spheroids in 3D culture reminiscent of osteosarcoma tumors. Institution: David Geffen School of Medicine, University of California, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Chinese Academy of Medical Sciences and Peking Union Medical College Team: Pichaya […]
New mechanistic insights into the tumorigenesis of DIPG yield a novel potential treatment: PPM1D inhibitors Institution: Emory School of Medicine Team: Mwangala Precious Akamandisa, Kai Nie, Rita Nahta, Dolores Hambardzumyan, and Robert Craig Castellino * Application: Use of VitroGel 3D for in vivo studies and assessing cell survival Disease model: Diffuse intrinsic pontine glioma (DIPG) […]
Three-dimensional hydrogels help to unravel the role and mechanism of action of BST-2 in breast cancer growth and metastasis and introduce a putative new therapy Institution: Carver College of Medicine, University of Iowa, Stony Brook University, Stanford University School of Medicine Team: Wadi D. Mahauad-Fernandez, Chioma M. Okeoma * Application: 3D tissue model to evaluate […]
