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Can I use VitroGel® Organoid Recovery Solution (MS04) for Collagen?

Our VitroGel® Organoid Recovery Solution (MS04) doesn’t work well for collagen. Some stem cells, such as MSCs, when cultured in hydrogel for a while, produce their own ECM (mostly collagen), which will further crosslink the hydrogel. In such cases, an enzyme or proteinase needs to be added.