Xeno-Free Hydrogels for 3D Cell Culture

Over 300+ publications and references.

VitroGel® is a biofunctional animal-free hydrogel for 3D cell culture.  Achieve 3D cell culture assays in less than 20 minutes with consistent results.

Xeno-Free Hydrogel

Room Temp Stable

Easy Cell Harvesting

Lot-to-Lot Consistency

Adaptable for
High-Throughput

APPLICATION NOTESRESEARCH HIGHLIGHTS

Healing Messengers: How Migrasomes and VitroGel® 3D Team Up for Skin Repair

Uncovering the power of fibroblast-derived migrasomes in wound healing with the help of VitroGel® 3D’s advanced 3D culture system Effective skin wound healing requires precise cell–cell communication and coordination across tissue types. However, [...]

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Uncovering Melanoma Plasticity Under Mechanical Confinement With VitroGel®

VitroGel® Cell Invasion Assay Kit empowers researchers to model cancer invasion under physiologically relevant 3D conditions. Melanoma, a deadly form of skin cancer, is notorious for its ability to switch between growing and [...]

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Uncovering the Role of Tumor-Associated Macrophages in Ovarian Cancer Therapy Using VitroGel® Models

VitroGel® ORGANOID 3 turns tumor–immune interactions into clear insights without the variability of animal-based matrices. A major challenge in ovarian cancer is chemotherapy resistance, often driven by the tumor’s immune microenvironment. Traditional culture [...]

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Dynamic VitroGel® Culture Promotes the Development of Insulin-Producing Taste Organoids

VitroGel® empowers dynamic 3D organoid growth, revealing taste biology and beyond. Studying taste receptor cell biology is challenging due to their complex structure, short lifespan, and limited survival in vitro. Traditional static cultures [...]

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Unlocking Gastric Cancer’s Immune Evasion Secrets with a Key Enzyme and Xeno-Free VitroGel®

VitroGel® RGD enables critical invasion assays to reveal the role of SPTSSA in tumor progression Gastric cancer (GC) is a deadly global health threat, often diagnosed too late due to its aggressive spread [...]

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Cracking the Code of Skin Cancer Progression with VitroGel® Hydrogel Matrix

Using VitroGel® to model tumor–stroma crosstalk in 3D and uncover new therapeutic targets in skin cancer. Solar UV-induced skin cancers, like cutaneous squamous cell carcinoma (cSCC), are driven not only by cancer cells [...]

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3D Cell Culture Modeling of Nasopharyngeal Carcinoma Progression with Xeno-free VitroGel® Hydrogel Matrix

Both VitroGel® Hydrogel Matrix and VitroGel® Cell Recovery Solution streamline 3D cell culture and cell isolation for high-impact studies of the tumor microenvironment. Understanding the mechanisms driving nasopharyngeal carcinoma (NPC) progression and metastasis [...]

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Advancing Personalized Meningioma Models with VitroGel® ORGANOID-3

VitroGel® ORGANOID-3 enabled the successful creation of patient-derived 3D meningioma models that closely mimicked primary tumor structure, biomarker expression, and epigenetic profiles in a xeno-free, reproducible system. Meningioma treatment faces significant hurdles, particularly [...]

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VitroGel® Takes the Fight to Fibrosis – Naringin Halts EMT in Lung Cells

VitroGel® takes the fight to fibrosis—making cell invasion studies faster, clearer, and more reliable. Pulmonary fibrosis, especially when triggered by toxins such as paraquat, is a life-threatening condition driven by inflammation, epithelial-mesenchymal transition [...]

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Evaluating Spheroid Invasion with VitroGel® Hydrogel Matrix in VitroPrime™ Ultra-Low Attachment, U-Bottom, 96-well Plate

Introduction Spheroid invasion assays offer a physiologically relevant three-dimensional (3D) in vitro model for studying cancer cell behavior, surpassing the limitations of traditional two-dimensional (2D) cultures [1]. Spheroids are compact cell aggregates that [...]

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VitroGel® at the Frontlines: Enabling 3D Modeling of Venous Invasion in Pancreatic Cancer

This study leveraged VitroGel®’s hydrogel system to model the tumor microenvironment and uncover the role of TIMP1 in driving venous invasion in pancreatic cancer. Hydrogel: VitroGel® Hydrogel Matrix (VHM01) Pancreatic ductal adenocarcinoma (PDAC) [...]

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Bringing the Brain to the Bench: A Microfluidic BBB Model for Tumor Interaction Studies

VitroGel® IKVAV was a key component that enabled stable vessel formation, proper cellular organization and functional BBB behavior in the 3D microfluidic model. Hydrogel: VitroGel® IKVAV (Cat. No: TWG007) The blood-brain barrier (BBB) [...]

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Advancing Bone Regeneration with Xeno-free VitroGel® System

VitroGel® Hydrogel Matrix enables the controlled delivery of bioactive Qu-SeNPs, accelerating bone defect healing and enhancing therapeutic potential for regenerative medicine. Hydrogel: VitroGel® Hydrogel Matrix (Cat. No: VHM01) The development of biomimetic hydrogels [...]

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VitroGel®-Enhanced 3D Culture Models Reveal the Potential of Basroparib in Overcoming MEK Inhibitor Resistance in KRAS-Mutated Colorectal Cancer

VitroGel® supports 3D spheroid models for evaluating basroparib’s efficacy in overcoming MEK inhibitor resistance in KRAS-mutated colorectal cancer. Hydrogel:VitroGel® RGD (Cat. No: TWG003) The study on basroparib’s role in overcoming MEK inhibitor resistance [...]

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3D Bioprinting Paves the Way for Fertility Preservation with VitroINK®

VitroINK® provided a xeno-free, structurally supportive bioink that enabled the precise 3D bioprinting of a functional testis model, facilitating cell viability, maturation, and in vitro spermatogenesis research. Fertility preservation following pediatric cancer therapy [...]

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News & Events

TheWell Bioscience Launches VitroGel® NEURON, a First-Of-Its-Kind Synthetic Hydrogel for Superior 3D, 2D Neuronal Cell Culture and Beyond

Monmouth Junction, NJ –  TheWell Bioscience Inc., a leader in advanced 3D cell culture platforms [...]

Xeno-Free 2D and 3D Neuron Culture Made Easy with VitroGel® NEURON

VitroGel® NEURON is a xeno-free hydrogel designed to closely mimic the native extracellular matrix, supporting [...]

Tracking Progress: Key Milestones Toward Animal-Free Research with NAMs

Discover why VitroGel® is the leading animal-free hydrogel.

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