Unique Injectable Properties of VitroGel®
From hydrogel to soft hydrogel back to hydrogel, the VitroGel® hydrogel system has unique shear-thinning and rapid recovery rheological properties for long-term injectable status ideal for animal injection, bioprinting, droplet formation, and lab automation.
Stable Soft Hydrogel
A stable soft hydrogel forms once VitroGel® solution mixed with cell medium or buffer like PBS. The hydrogel mixture maintains a long injectable status.
Gel-Sol Transition
A gel-sol transition happens when the soft hydrogel is subjected to a mechanical shearing force (e.g., injection or pipetting), causing the mixture to become free-flowing..
Rapid Hydrogel Recovery
Rapid hydrogel status recovery with a sol-gel transition once the shearing force ceases, restoring its mechanical strength and becoming hydrogel again.
The rheological data shows the shear-thinning and rapid rheological property of VitroGel®
Extremely smooth injectability for versatile applications
Room temperature stable for sample preparation.
No more needle/tip clogging issue.
Long-term injectable status. No rush for injection for stress-free operations.
Synthetic, xeno-free system for consistent data and biomedical potentials.
With the unique injectable property and above features, VitroGel® can be used for in vivo cells/drug delivery with excellent retention, bioprinting, droplet formation, and laboratory automation.
Animal Injection
Easy room temperature operation
Excellent for both PDX and CDX models
Maintains homogeneous cell suspension
Trusted by leading global CROs and Pharma
Excellent cell retention & growth kinetics
Supports most major cell types with 100% growth rate
VitroGel® is ideal for animal injection due to its injectability, biocompatibility, consistent viscosity, and mechanical properties that ensure smooth and reproducible injections. Its xeno-free composition reduces immune reactions and mimics the natural extracellular matrix to support cell growth and viability.
With its unique injectable property, cells or compounds can be pre-mixed with VitroGel® and maintained as a homogeneous mixture in the injectable state for in vivo applications.
“The VitroGel® worked extremely well and was very smooth to work with as opposed to the Matrigel. Upon observation today, the “tumor only” and “tumor and Matrigel” mice appear to have darkening and bruising at the injection site, where the “tumor and VitroGel®” and “tumor, VitroGel® and cisplatin” do not have any darkening or bruising at the injection sites.”
Source: Patient-Derived Xenograft Using Xeno-Free VitroGel® System in Comparison to Animal-based Matrigel
Bioprinting
VitroINK® – A New Generation of Bioinks
No UV Crosslink
No Heat Curing
No Chemical Crosslink
VitroINK® is ideal for bioprinting due to its tunable viscosity and mechanical properties, which ensure precise and consistent extrusion through bioprinter nozzles, allowing for the creation of intricate and stable 3D structures.
Its biocompatible, xeno-free composition supports cell viability and proliferation, essential for producing functional tissue constructs. Additionally, VitroINK® bioinks are room temperature stable, making them much easier to handle. Cells can be either pre-mixed or mixed directly with the bioink by using a dual syringe system. Multiple biological functional components can be incorporated with VitroINK® for different applications.
Works with any
extrusion-based bioprinter
The unique mixing device ensures no air bubble when mixing cells with VitroINK®
Excellent extrusion uniformity and shape fidelity
Bio-functional formulation for cell-matrix interactions
High cell viability after printing
Supports FRESH printing
Droplet Formation
Crosslink with cell medium, No oil needed
Easy Setup – Work w/ or w/o microfluidic chips
Tunable Hydrogel for adjustable droplet size
High Cell Viability & Easy Cell Harvesting
VitroGel® hydrogel is ideal for droplet formation because its unique hydrogel properties enable precise control over gelation, allowing it to form stable and uniform droplets.
The hydrogel’s mechanical characteristics can be finely tuned, ensuring consistency and reproducibility in droplet size and shape. Additionally, its biocompatible and xeno-free composition supports the encapsulation and viability of cells or biomolecules within the droplets, making it suitable for various applications, including 3D cell culture, drug screening, and regenerative medicine.
Crosslink with cell medium, oil is not required
Easy Setup – work w/ or w/o microfluidic chips
MSC 3D Culture Scale-up
Bead Droplet Method
Tunable hydrogel for adjustable droplet size and shape
High cell viability and easy cell harvesting
Lab Automation
Easy-to-use, room temperature operation
Applicable for both VitroGel® and VitroINK®
Works with all types of lab automation equipment
Excellent for VitroPrime™ Spread-Attach Plate
VitroGel® hydrogel is room temperature stable, and its unique shear-thinning and rapid recovery rheological properties allow for easy dispensing in laboratory automation and high throughput applications.
Works with all types of
lab automation equipment
Excellent with
VitroPrime™
Spread-Attach Plate
