Author Archives: Eryka Bantolino

Bringing a Small Intestine Model into the Laboratory

Vitrogel increased cell proliferation by a factor of 1.70 compared to a cell control.

Institutions:University of Graz, Austria Team:Zeiringer, S., Wiltschko, L., Glader, C., Reiser, M., Absenger-Novak, M., Frölich, E., & Roblegg, E. Disease Model:Intestinal Absorption Hydrogel:VitroGel® Hydrogel Matrix Three hydrogels were tested as possible extracellular matrix mimics to establish a viable model of the human small intestine in the lab. The extracellular matrix, or ECM, is a network […]

Bulking up Stem Cells to Get into the Healing Game

MSC expansion in vertical-wheel bioreactors utilizing a fed-batch process while utilizing VitroGel

Institutions:Rutgers University Team:Teryek, M., Jadhav, P., Bento, R., and Parekkadan, B. Disease Model:Liver & Kidney Failure Hydrogel:VitroGel® MSC Mesenchymal stem cells (MSCs) can be grown up to scale and genetically tuned for therapeutic deployment using a combination of a xeno-free hydrogel system and a vertical wheel bioreactor. In recent years we have been able to […]

Finding Living Needles in a 3D Haystack

Experimental setup for optical coherence tomography (OCT) imaging with cells encapsulated in VitroGel 3D

Institutions:National Institute of Standards and Technology (NIST) and National Institutes of Health (NIH), Maryland, USA Team:Babakhanova, G., Agrawal, A., Arora, D., Horenberg, A., Budhathoki, J.B., Dunkers, J.P., Chalfoun, J., Bajcsy, P., & Simon Jr., C.G. Disease Model:Tissue Repair Hydrogel:VitroGel® 3D The use of 3D optical coherence tomography (OCT) proves to be a quick, easy, and […]

An Artificial Womb for the Womb

Images on oocyte maturation of the follicles in different culture systems using VitroGel 3D, RGD, and IYR

Institutions:Shengjing Hospital of China Medical University & University of British Columbia Team:Zhao, X., Zhang, S., Gao, S., Chang, H.-M., Leung, P.C.K., and Tan, J. Disease Model:Ovarian Cancer Hydrogel:VitroGel® RGD Three-dimensional cell culture in a hydrogel that was augmented with laminin peptides supports follicle tissue maintenance and hormonal function ex vivo. The human ovary contains an […]

Taking Away a Notch in the Belt of Pancreatic Cancer

kruppel-like-factor-notch-signaling-pancreatic-adenocarcinoma-vitrogel

Institutions:Taipei Medical University, National Cheng Kung University, National Sun Yat-Sen University, and the National Institute of Cancer Research, Taiwan, and the Mayo Clinic. Team:Tsai, Y.-C., Cheng, K.H., Jiang, S.S., Hawse, J.R., Chuang, S.E., Chen, S.L., Huang, T.-S., and Ch’ang, H.-J. Disease Model:Pancreatic Cancer Hydrogel:VitroGel® Hydrogel Matrix A mouse model for pancreatic cancer is developed that […]

Cutting Colon Cancer Out Properly

Blot analysis of EMT markers and NY-YA isoforms in CRC cell lines and optical microscopy images of Empty, NF-YAs and NF-YAI 3D colonies morphology in Vitrogel matrix

Institutions:University of Modena and Reggio Emilia, University of Milan, Italy Team:Rigillo, G., Belluti, S., Campani, V., Ragazzini, G., Ronzio, M., Miserocchi, G., Bighi, B., Cuoghi, L., Mularoni, V., Zappavigna, V., Dolfini, D., Mercatali, L., Alessandrini, A., and Imbriano, C. Disease Model:Colon Cancer Hydrogel:VitroGel® 3D A protein that binds DNA and can trigger colorectal cancer apparently […]

No Relaxing in the Fight Against Liver Cancer

VitroGel matrix stiffness regulates the cancer stem‑like cell phenotype in hepatocellular carcinoma

Institutions:Lanzhou University, China Team:Wei, J., Yao, J., Yang, C., Mao, Y., Zhu, D., Xie, Y., Liu, P., Yan, M., Ren, L., Lin, Y., Zheng, Q., & Li., X. Disease Model:Liver Cancer Hydrogel:VitroGel® 3D Cancer cell stiffness was measured by atomic force microscopy in tumors taken from liver cancer patients. The findings suggest that there are […]

Using the Xeno-free VitroGel® Cell Invasion Assay Kits to Perform both Traditional and Complex Cell Mobility Studies

VitroGel Cell Invasion Assay Kit

Introduction Cell invasion is a dynamic process that is critical during embryonic development, immunosurveillance, and wound healing. Cell invasion is an orchestrated mechanism that occurs due to cell attachment to the extracellular matrix (ECM) followed by proteolytic degradation of the ECM, resulting in movement towards the newly invaded site. Cell invasion is not only crucial […]