Author Archives: thewellbio

TheWell Bioscience Announces Launch of VitroGel® Organoid Recovery Solution for Fast and Safe Harvesting of Organoids/Cells with High Yields

TheWell Bioscience has launched a newly engineered version of its cell recovery solution for researchers to speed the organoid/cell harvesting from both animal-based extracellular matrix (ECM) and synthetic hydrogels. NEW BRUNSWICK, N.J., Feb. 21, 2023 /PRNewswire/ — TheWell Bioscience, a pioneer of 3D cell culture platforms for precision medicine, cell therapy, and biomanufacturing, releases a newly engineered […]

Choking Out Lymphoma in Dogs – Intestinal T-Cell Lymphoma

Institutions: Rakuno Gakuen University School of Veterinary Medicine, and Osaka Metropolitan University, Japan Team: Yamazaki, H., Tanaka, T., Nishida, H., Hatoya, S., and Akiyoshi, H. Disease Model: Intestinal T-Cell Lymphoma Hydrogel: VitroGel® RGD The drug evofosfamide is active under low oxygen conditions, those same conditions that tend to aid in lymphoma tumor growth. This fortuitous […]

New Product: VitroGel® Organoid Recovery Solution

New Product Launch We are excited to launch our new recovery solution for organoid and 3D cell cultures.  The new non-enzymatic recovery solution is not limited to cell harvesting from our VitroGel hydrogels but as a replacement for cell harvesting from animal-based ECM cultures.  This new recovery solution boasts a fast 2-min dissociation of animal-based […]

Generation of Tumor Cell Spheroids in Miniaturized Nanoliter Droplets Using Xeno-free VitroGel Hydrogel Matrix

The Droplet Microarray Platform The Droplet Microarray (DMA) is made of hydrophilic spots on a superhydrophobic background that allows formation of separated and homogeneous droplets in the sub-microliter range on a planar surface. Precise filling of the DMA spots, which are typically 350-1000 µm in size, is performed using a nanoliter liquid dispenser. A capacity […]

2022 Year-End Christmas and New Year Holiday Business Hours

2022 Year-End Christmas and New Year Holiday Ofice and Warehouse Schedule December 22, 2022:   Last day of shipping in December. December 23-26, 2022:  Offices and Warehouse CLOSED December 27-30, 2022:  Offices OPEN | Warehouse Closed. December 31 – January 2, 2023:  Offices and Warehouse CLOSED. January 3, 2023 – Offices and Warehouse reopens. Resume all […]

Functionalizing Xeno-Free VitroINK® Bioinks to Promote Cell-Cell Interactions Between Human-Induced Pluripotent Stem Cell-Derived Testis Cells for In Vitro Spermatogenesis

Introduction The differentiation of sperm, termed spermatogenesis, is coordinated by somatic cells within the seminiferous tubules of the testis niche. Spermatogonial stem cells – the progenitor cells which give rise to sperm – form physical attachments to somatic cells called Sertoli cells, which guide their differentiation through a program of paracrine signaling.1 Human in vitro […]

VitroGel Hydrogel Injection

VitroGel xeno-free hydrogels are excellent for injection and a superior alternative to the animal-based extracellular matrix or plant-based hydrogel for xenograft, targeted delivery, control release, and cell therapy for tissue engineering. Simply mix hydrogel solution with cells/compounds at room temperature, the hydrogel is ready for injection in 5-15 minutes. The system is biocompatible without showing […]

ISSCR 2022 – International Society for Stem Cell Research

TheWell Bioscience is excited to be exhibiting at ISSCR 2022 (International Society for Stem Cell Research) on June 15-11 in San Francisco, CA. Stop by booth# 541  to learn about our VitroGel®, our robust, scalable, xeno-free line of hydrogels for: Organoids | Stem Cells | MSCs | Cancer Spheroids | Invasion Assay | Co-Culture | […]

A New Valid Rhabdomyosarcoma Spheroid Culture Model for in Vitro Evaluation of Hypericin-Based Photodynamic Therapy

Institution:University Hospital Marburg, Marburg, Germany Team:Hempfling L., Adamus A., Wagner B.R., Engel N., and Seitz, G. Application:Creation of a 3D cell culture scenario for the study of the efficacy of photodynamic therapy as an anti-cancer treatment. Disease Model:Pediatric alveolar rhabdomyosarcoma Hydrogel:VitroGel® RGD Photodynamic therapy (PDT) has shown promise in the treatment of certain malignancies that […]

Restraint Upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction Between Quasi-Static Load and the mTOR Pathway

Institution:Royal Veterinary College, London Team:Caetano-Silva S., Simbi B.H., Marr N., Hibbert A., Allen S.P., and Pitsillides, A.A. Application:Creation of a cell culture environment that emulates a quasi-static load to test mechanical influences on limb growth. Disease Model:Mouse limb skeletal development Hydrogel:VitroGel® 3D The factors that control skeletal limb development in mammals are only partially understood. […]