Author Archives: thewellbio

Characterization of Lipopolysaccharide-Induced Prostate Cancer Formation and Possible Amelioration of This Process by the Antibiotic Trichostatin A

Institution:Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, China Team:Tang S., Lian X., Cheng H., Guo J., Ni D., Huang C., Gu X., Meng H., Jiang J., and Li, X. Application:Establishment of a tissue-mimicking 3D cell culture to test tumor formation, progression, and inhibition in prostate cell lines. Disease Model:Prostate Cancer Hydrogel:VitroGel® RGD The progression of […]

Validation of Low-Intensity Pulsed Ultrasonic Systems That Can Modulate the Doses That Are Delivered to Biological Targets

Institution:The BioRobotics Institute, Pisa, Italy Team:Fontana F., Iberite F., Cafarelli A., Aliperta A., Baldi G., Gabusi E., Dolzani P., Cristo S., Lisignoli G., Pratellesi T., Dumont E., Jr., and Ricotti, L. Application:Addition of a microbiological growth environment to a low-intensity ultrasound chamber to test for external contamination. Disease Model:Ultrasound diagnostics Hydrogel:VitroGel® 3D Ultrasound (US) is […]

Delivery of Cannabidiol via Extracellular Vesicles Improves the Cytotoxic Effects of Chemotherapy on Triple Negative Breast Cancer Cells

Institution:Florida State University Team:Patel N., Kommineni N., Surapaneni S.K., Kalvala A., Yuan X., Gebeyehu A., Arthur P., Duke L.C., York S.B., Bagde A., Meckes D.G., Jr., and Singh, M. Application:Creation of a 3D cell culture microenvironment for the delivery of CBD to breast cancer cells via extracellular vesicles. Disease Model:Breast Cancer Hydrogel:VitroGel® LDP2 Chemotoxic agents […]

RNF208, an Estrogen-Inducible E3 Ligase, Targets Soluble Vimentin to Suppress Metastasis in Triple-Negative Breast Cancers

Institution:Seoul National University, Seoul, South Korea; Yonsei University Medical College, Seoul, South Korea; University of Tsukuba, Tsukuba, Japan; National Cancer Center Research Institute, Tokyo, Japan Team:Pang K., Park J., Ahn S.G., Lee J., Park Y., Ooshima A., Mizuno S., Yamashita S., Park K.-S., Lee S.-Y., Jeong J., Ushijima T., Yang K.-M., and Kim S.-J Application:Xenografting […]

Patient-Derived Tumoroids in 3D Xeno-Free Hydrogel with Automated Biomarker Detection

Abstract 3D cell models like organoid and patient-derived tumoroid are becoming increasingly important for personalized medicine, drug screening and cell therapy. Such 3D models are highly relied on for microenvironment recapitulation.  A reliable xeno-free hydrogel system that can closely mimic the natural extracellular matrix (ECM) is extremely important to replace the animal-based extracellular matrix to […]

AACR 2022 – American Association for Cancer Research

TheWell Bioscience is excited to be exhibiting at AACR 2022 (American Association for Cancer Research) on April 10-13 in New Orleans, LA. Stop by booth# 1244 to learn about our VitroGel®, our robust, scalable, xeno-free line of hydrogels for: Organoids | Stem Cells | MSCs | Cancer Spheroids | Invasion Assay | Co-Culture | Angiogenesis […]

Blebs Play an Important Role in Promoting Resistance to Programmed Cell Death in Metastatic Melanoma Cells

Institution:UT Southwestern Medical Center Team:Weems A.D., Welf E.S., Driscoll M.K., Mazloom-Farsibaf H., Chang B.-J., Weiss B.G., Chi J., Dean K.M., Fiolka R., and Danuser, G. Application:In vitro encapsulation of melanoma cells either to allow or to block substrate adhesion Disease Model:Melanoma Hydrogel:VitroGel® RGD and VitroGel® 3D Cancer progression in pre-tumor cells is controlled by a […]

Estrogen Induces Apoptosis of Breast Cancer Cells in Aromatase Inhibitor Resistant Tumors

Institutions: 1. Department of Cancer Biology, Beckman Research Institute of the City of Hope, 2. Kyushu University, 3. Integrative Genomics Core, Beckman Research Institute of the City of Hope, 4. Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center Team: Mori H1, Saeki K1, Chang G1, Wang J3, Wu X3, Hsu […]

Conversion of Normal Cells to Pro-tumorigenic Lung Cancer Cells Can Occur by the Transfer of Micro RNAs From Circulating Extracellular Vesicles

Institution: Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy Team: Pontis F., Roz L., Mensah M., Segale M., Moro M., Bertolini G., Petraroia I., Centonze G., Ferretti A.M., Sautoni P., Pastorino U., Fortunato, O., and Sozzi, G. Application: In vitro interaction among extracellular vesicles to evaluate their pro-tumorigenic activity Disease Model: Lung Cancer Hydrogel: VitroGel® […]

Society for Laboratory Automation and Screening 2022

TheWell Bioscience is excited to be exhibiting at SLAS (Society for Laboratory Automation and Screening) 2022 this coming Feb 7-9 in Boston, MA. Stop by booth# 2440 to learn about our VitroGel®, our robust, scalable, xeno-free line of hydrogels for: Organoids | Stem Cells | MSCs | Cancer Spheroids | Invasion Assay | Co-Culture | […]