Category Archives: Research Highlights

Taking Away a Notch in the Belt of Pancreatic Cancer

kruppel-like-factor-notch-signaling-pancreatic-adenocarcinoma-vitrogel

Institutions:Taipei Medical University, National Cheng Kung University, National Sun Yat-Sen University, and the National Institute of Cancer Research, Taiwan, and the Mayo Clinic. Team:Tsai, Y.-C., Cheng, K.H., Jiang, S.S., Hawse, J.R., Chuang, S.E., Chen, S.L., Huang, T.-S., and Ch’ang, H.-J. Disease Model:Pancreatic Cancer Hydrogel:VitroGel® Hydrogel Matrix A mouse model for pancreatic cancer is developed that […]

Cutting Colon Cancer Out Properly

Blot analysis of EMT markers and NY-YA isoforms in CRC cell lines and optical microscopy images of Empty, NF-YAs and NF-YAI 3D colonies morphology in Vitrogel matrix

Institutions:University of Modena and Reggio Emilia, University of Milan, Italy Team:Rigillo, G., Belluti, S., Campani, V., Ragazzini, G., Ronzio, M., Miserocchi, G., Bighi, B., Cuoghi, L., Mularoni, V., Zappavigna, V., Dolfini, D., Mercatali, L., Alessandrini, A., and Imbriano, C. Disease Model:Colon Cancer Hydrogel:VitroGel® 3D A protein that binds DNA and can trigger colorectal cancer apparently […]

No Relaxing in the Fight Against Liver Cancer

VitroGel matrix stiffness regulates the cancer stem‑like cell phenotype in hepatocellular carcinoma

Institutions:Lanzhou University, China Team:Wei, J., Yao, J., Yang, C., Mao, Y., Zhu, D., Xie, Y., Liu, P., Yan, M., Ren, L., Lin, Y., Zheng, Q., & Li., X. Disease Model:Liver Cancer Hydrogel:VitroGel® 3D Cancer cell stiffness was measured by atomic force microscopy in tumors taken from liver cancer patients. The findings suggest that there are […]

Cooking Up Capillaries – Organ-On-A-Chip with HUVECs

Institutions: National Chung Hsing University, Taiwan Team: Lin, Y.-T., Tung Y.-T., Wong, J.-Y., and Wang, G.-J. Disease Model: Microvascular System Biomimetics Hydrogel: VitroGel® RGD Researchers find a facile way to create synthetic microscopic vessels in the laboratory utilizing VitroGel RGD. Biomimetics is the study of how we can create nature-inspired materials for human use. One […]

Better in 3D than 2D – Celecoxib 3D Anti-cancer Testing

Institutions: University of Naples, Italy Team: Venuta, A., Nasso, R., Gisonna, A., Iuliano, R., Montesarchio, S., Acampora, V., Sepe, L., Avagliano, A., Arcone, R., Arcucci, A., and Ruocco, M.R. Disease Model: Melanoma Hydrogel: VitroGel® Hydrogel Matrix A powerful potential anti-melanoma drug, celecoxib, is effective in 2D cultures. This new study shows that it is also […]

Fishing for Therapies for Eye Cancer – Uveal Melanoma

Institutions: Leiden University, The Netherlands; University of Liverpool, UK; & Friedrich-Alexander-Universität, Germany Team: Yin, J., Zhao, G., Kalirai, H., Coupland, S.-E., Jochemsen, A.G., Forn-Cuní, G., Wierenga, A.P.A., Jager, M.J., Snaar-Jagalska, B.E., and Groenewoud, A. Disease Model: Uveal Melanoma Hydrogel: VitroGel® Hydrogel Matrix Zebrafish embryos were tested as a viable model to perform drug screening for […]

Clay is Good to the Bone – Osteoporosis Disease Model

Institutions: King Fahd University, Saudi Arabia; Royal College of Surgeons in Ireland Medical University, Bahrain; and the National University of Computer and Emerging Sciences, Pakistan Team: Abduljauwad, S.N., Habib, T., and ur-Rehman, H. Disease Model: Osteoporosis Hydrogel: VitroGel® 3D The combination of clay microparticles and VitroGel hydrogel appears to promote osteogenesis in human mesenchymal stem […]

Shaking Up Tumors with Sound and Bubbles

Institutions: Cheng Hsin General Hospital and National Taiwan University, Taiwan Team: Chen, K.-W., Hsu, P.-H., Huang, H.-L., Liu, H.-L., Lin, Y.-T., Hsu, C.-Y., Lin, J.-H., and Lin, Y.-H. Disease Model: Gastric Cancer Hydrogel: VitroGel® 3D Antitumor drugs can be delivered to tumors with nanoparticles and microbubbles, and then the uptake of the drugs can be […]

Fighting Pancreatic Cancer – Two Drugs are Better Than One

Institutions: Sungkyunkwan University, South Korea and the University of Oxford Team: Hong, H., Barczak W., Park, S., Heo, J.S., Ooshima, A., Munro, S., Hong, C.P., Park, J., An, H., Park, J.O., Park, S.H., La Thangue, N.B., and Kim, S.-J. Disease Model: Pancreatic Cancer Hydrogel: VitroGel® Hydrogel Matrix A combination therapy of two antitumor drugs shows […]