Category Archives: Research Highlights

Knocking Down Doors to Find Cancer Therapies Using Anti-Kinase Strategies

Institutions:University of South China, The University of Miami, University of Southern Califormia, The Ohio State University, The Ohio State University Wexner Medical Center, and University of California Team:Cui, J., Dean, D., Hornicek, F.J., Pollock, R.E., Hoffman, R.M., and Duan, Z. Application:3D cell culture Disease Model:Liposarcoma Hydrogel:VitroGel® 3D The use of a 3D cell culture was […]

Shining a (near-infrared) Light to Find Cancer

Institutions:Shandong University and University of Jinan, China Team:Chen Y., Zhang X., Xiaoya L., Wu H., Zhang D., Zhu B., and Huang S. Application:HSC2 or CAL-27 cells in VitroGel xenografted into nude mice- identification of hypoxic levels in vivo Disease Model:Cancer progression and diagnosis Hydrogel:VitroGel® 3D Kit Cancer cells grown in VitroGel 3D can be detected […]

Check the MAP(K): Cancer Driver Signals on Pathway to Change Lanes

Institutions: Universitätsmedizin Berlin, and the German Cancer Consortium Team: Uhlitz F., Bischoff, P., Peidli, S., et al. Application: Cancer Research Disease Model: Colorectal Cancer Viability Analysis: Cyto3D® Live-Dead Assay Kit Mitogen-activated protein kinases divert the normal developmental path in colorectal cells onto a road to cancer, and distinct RNA signals reveal this change. The sequence […]

Going 3D to Fight Cancer

Institutions:Rutgers Team:Bhatt, R., Ravi, D., Evens, A.M., and Parekkadan, B. Application:Cancer Research Disease Model:Lymphoma Hydrogel:VitroGel® Hydrogel Matrix Cells propagated in a hydrogel 3D cell culture grow more slowly than they do in 2D cultures but exhibit more biological realism which is critical for cancer drug screening and therapy. Cancer progression is a very complex process, […]

3D Bioprinting of an Implantable Xeno-free Vascularized Human Skin Graft

Institutions: Yale University School of Medicine and several other institutions Team: Baltazar T., Jiang B., Moncayo A., Merola J., Albanna M., Salzman W.M., and Pober, J.S. Application: Production of xeno-free bioink for 3D bioprinting of human skin cell grafts Disease Model: Human skin substitute Hydrogel: VitroGel® Hydrogel Matrix In many circumstances, bioengineered skin substitutes are […]

Inhibition of CDK7-dependent Transcriptional Addiction is a Potential Therapeutic Target in Synovial Sarcoma

Institutions: University of Miami, UCLA, USC, and the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Team: Li X., Dean D.C., Yuan J., Temple T.H., Trent J.C., Rosenberg A.E., Yu, S., Hornicek F.J., and Duan, Z. Application: Mimicking the 3D tumor cell environment for cancer cell proliferation assays and therapeutic strategies […]

Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways

Institutions: Chinese Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China Team: Zhang B., Xiao M., Cheng X., Yu B., Chen H., Yu Q., and Qiu, L. Application: Creating and injectable hydrogel for the tracking of dental pulp regeneration via stimulation of stem cells Disease Model: Dental pulp regeneration Hydrogel: VitroGel® RGD Dental […]

VitroGel® RGD Hydrogel Improves the Therapeutic Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Phosgene-Induced Acute Lung Injury in Rats

TheWell Bioscience VitroGel® RGD and VitroGel® 3D speed up how fast joints can repair themselves Institutions: Fudan University, Shanghai, China Team: Ding J., Sun Y., He D., Shao Y., Liu F., Zhang L., and Shen, J. Application: To aid mesenchymal stem cell culturing and delivery for the healing of lung tissue injury. Disease Model: Phosgene-induced […]

VitroGel® RGD-derivatized Hydrogels Can Support Cartilage Wound Healing

TheWell Bioscience VitroGel® RGD and VitroGel® 3D speed up how fast joints can repair themselves Institutions: Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Bolonga, Italy Team: Manferdini C., Trucco D., Saleh Y., Gabusi E., Dolzani P., Lenzi E., Vannozzi, L., Ricotti, L., and Lisignoli G. Application: To aid the healing process of damaged joint cartilage using […]

Centrosome Positioning in Migrating Dictyostelium Cells

  Institution: Ludwig Maximillian University, Munich, Germany Team: Ishikawa-Ankerhold H., Kroll J., van den Heuvel., Renkawitz J., and Müller-Taubenberger A. Application: New insight into how cells move through the environment in an amoeba-like fashion as sometimes occurs during wound healing. Disease Model: Wound healing Hydrogel: VitroGel® Hydrogel Matrix When cells move from one place to […]