Category Archives: Research Highlights

RNF208, an Estrogen-Inducible E3 Ligase, Targets Soluble Vimentin to Suppress Metastasis in Triple-Negative Breast Cancers

Institution:Seoul National University, Seoul, South Korea; Yonsei University Medical College, Seoul, South Korea; University of Tsukuba, Tsukuba, Japan; National Cancer Center Research Institute, Tokyo, Japan Team:Pang K., Park J., Ahn S.G., Lee J., Park Y., Ooshima A., Mizuno S., Yamashita S., Park K.-S., Lee S.-Y., Jeong J., Ushijima T., Yang K.-M., and Kim S.-J Application:Xenografting […]

Blebs Play an Important Role in Promoting Resistance to Programmed Cell Death in Metastatic Melanoma Cells

Institution:UT Southwestern Medical Center Team:Weems A.D., Welf E.S., Driscoll M.K., Mazloom-Farsibaf H., Chang B.-J., Weiss B.G., Chi J., Dean K.M., Fiolka R., and Danuser, G. Application:In vitro encapsulation of melanoma cells either to allow or to block substrate adhesion Disease Model:Melanoma Hydrogel:VitroGel® RGD and VitroGel® 3D Cancer progression in pre-tumor cells is controlled by a […]

Estrogen Induces Apoptosis of Breast Cancer Cells in Aromatase Inhibitor Resistant Tumors

Institutions: 1. Department of Cancer Biology, Beckman Research Institute of the City of Hope, 2. Kyushu University, 3. Integrative Genomics Core, Beckman Research Institute of the City of Hope, 4. Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center Team: Mori H1, Saeki K1, Chang G1, Wang J3, Wu X3, Hsu […]

Conversion of Normal Cells to Pro-tumorigenic Lung Cancer Cells Can Occur by the Transfer of Micro RNAs From Circulating Extracellular Vesicles

Institution: Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy Team: Pontis F., Roz L., Mensah M., Segale M., Moro M., Bertolini G., Petraroia I., Centonze G., Ferretti A.M., Sautoni P., Pastorino U., Fortunato, O., and Sozzi, G. Application: In vitro interaction among extracellular vesicles to evaluate their pro-tumorigenic activity Disease Model: Lung Cancer Hydrogel: VitroGel® […]

Glucose Metabolism in Obese Mice can be Improved by Implantation with Photoactivated Adipose Stem Cells

Institution: Southwest Medical University, Luzhou, Sichuan, China Team: Zhu L., Feng Z., Shu X., Gao Q., Wu J., Du Z., Li R., Wang L., Chen N., Li Y., Luo M., and Wu J. Application: In vivo implantation of adipose stem cells to ameliorate glucose intolerance in obese mice Disease Model: Type 2 Diabetes Hydrogel: VitroGel® […]

Establishing the First Co-Culture Model of Human Gastric Organoids and Dendritic Cells Using the Xeno-free VitroGel ORGANOID Hydrogel

Institutions: Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States Team: Michelle D. Chergne, Barkan Sidar, T. Andrew Sebrell, Humberto S. Sanchez, Kody Heaton, Francis J. Kassama, Mandi M. Roe, Andrew B. Gentry, Connie B. Chang, Seth T. Walk, Mark Jutila, James N. Wilking, and Diane Bimczok Application: A Synthetic Hydrogel, […]

Identification of a Novel Antitumor Small-Molecule Known as MKI-1 via Activation of PP2A in Breast Cancer

Institutions:Korea Institute of Radiological and Medical Sciences, Seoul, South Korea; Radiological and Medico-Oncological Sciences, University of Science and Technology, Daejeon, South Korea; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea; Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, South Korea […]

miR-340 Restoration Promotes Macrophage Phagocytosis and Antitumor Immunity via Regulation of CD47 Expression

Institutions: Tianjin Medical University, Tianjin, China; Guangdong Pharmaceutical University, Guangzhou, China; University of Texas Southwestern Medical Center, Dallas, Texas, USA. Team: Xi q., Zhang J., Yang G., Zhang L., Chen Y., Wang C., Zhang Z., Guo X., Zhao J., Xue Z., Li Y., Zhang Q., Da Y., Liu L., Yao Z., and Zhang R. Application: […]

KLF7: Discovery of a Novel Therapeutic Target and Biomarker for High-Grade Serous Ovarian Cancer

Institution: Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Milan, Italy Team:De Donato M., Babini G., Mozzetti S., Buttarelli M., Ciucci A., Arduini G., De Rosa M. C., Scambia G., Gallo D. Application:Discovery of KLF7, a novel biomarker and therapeutic target for high-grade serous ovarian cancer Disease Model:Ovarian Cancer Hydrogel:VitroGel® […]

Mesenchymal Stromal Cell-Derived CXCL12 Affects Tumor Growth by Macrophage M1 to M2 Polarization

Institution: Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Team:Babazadeh S., Nassiri S. M., Siavashi V., Sahlabadi M., Hajinasrollah M., and Zamani-Ahmadmahmudi Z. Application:Identification of a new role for MSC-derived CXCL12 in M2 phenotypic switching of macrophages, affecting tumorigenesis in breast cancer cells Disease Model:Breast Cancer Hydrogel:VitroGel® RGD Studies over […]