Category Archives: Research Highlights

A New Valid Rhabdomyosarcoma Spheroid Culture Model for in Vitro Evaluation of Hypericin-Based Photodynamic Therapy

Institution:University Hospital Marburg, Marburg, Germany Team:Hempfling L., Adamus A., Wagner B.R., Engel N., and Seitz, G. Application:Creation of a 3D cell culture scenario for the study of the efficacy of photodynamic therapy as an anti-cancer treatment. Disease Model:Pediatric alveolar rhabdomyosarcoma Hydrogel:VitroGel® RGD Photodynamic therapy (PDT) has shown promise in the treatment of certain malignancies that […]

Restraint Upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction Between Quasi-Static Load and the mTOR Pathway

Institution:Royal Veterinary College, London Team:Caetano-Silva S., Simbi B.H., Marr N., Hibbert A., Allen S.P., and Pitsillides, A.A. Application:Creation of a cell culture environment that emulates a quasi-static load to test mechanical influences on limb growth. Disease Model:Mouse limb skeletal development Hydrogel:VitroGel® 3D The factors that control skeletal limb development in mammals are only partially understood. […]

Characterization of Lipopolysaccharide-Induced Prostate Cancer Formation and Possible Amelioration of This Process by the Antibiotic Trichostatin A

Institution:Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, China Team:Tang S., Lian X., Cheng H., Guo J., Ni D., Huang C., Gu X., Meng H., Jiang J., and Li, X. Application:Establishment of a tissue-mimicking 3D cell culture to test tumor formation, progression, and inhibition in prostate cell lines. Disease Model:Prostate Cancer Hydrogel:VitroGel® RGD The progression of […]

Validation of Low-Intensity Pulsed Ultrasonic Systems That Can Modulate the Doses That Are Delivered to Biological Targets

Institution:The BioRobotics Institute, Pisa, Italy Team:Fontana F., Iberite F., Cafarelli A., Aliperta A., Baldi G., Gabusi E., Dolzani P., Cristo S., Lisignoli G., Pratellesi T., Dumont E., Jr., and Ricotti, L. Application:Addition of a microbiological growth environment to a low-intensity ultrasound chamber to test for external contamination. Disease Model:Ultrasound diagnostics Hydrogel:VitroGel® 3D Ultrasound (US) is […]

Delivery of Cannabidiol via Extracellular Vesicles Improves the Cytotoxic Effects of Chemotherapy on Triple Negative Breast Cancer Cells

Institution:Florida State University Team:Patel N., Kommineni N., Surapaneni S.K., Kalvala A., Yuan X., Gebeyehu A., Arthur P., Duke L.C., York S.B., Bagde A., Meckes D.G., Jr., and Singh, M. Application:Creation of a 3D cell culture microenvironment for the delivery of CBD to breast cancer cells via extracellular vesicles. Disease Model:Breast Cancer Hydrogel:VitroGel® LDP2 Chemotoxic agents […]

RNF208, an Estrogen-Inducible E3 Ligase, Targets Soluble Vimentin to Suppress Metastasis in Triple-Negative Breast Cancers

Institution:Seoul National University, Seoul, South Korea; Yonsei University Medical College, Seoul, South Korea; University of Tsukuba, Tsukuba, Japan; National Cancer Center Research Institute, Tokyo, Japan Team:Pang K., Park J., Ahn S.G., Lee J., Park Y., Ooshima A., Mizuno S., Yamashita S., Park K.-S., Lee S.-Y., Jeong J., Ushijima T., Yang K.-M., and Kim S.-J Application:Xenografting […]

Blebs Play an Important Role in Promoting Resistance to Programmed Cell Death in Metastatic Melanoma Cells

Institution:UT Southwestern Medical Center Team:Weems A.D., Welf E.S., Driscoll M.K., Mazloom-Farsibaf H., Chang B.-J., Weiss B.G., Chi J., Dean K.M., Fiolka R., and Danuser, G. Application:In vitro encapsulation of melanoma cells either to allow or to block substrate adhesion Disease Model:Melanoma Hydrogel:VitroGel® RGD and VitroGel® 3D Cancer progression in pre-tumor cells is controlled by a […]

Estrogen Induces Apoptosis of Breast Cancer Cells in Aromatase Inhibitor Resistant Tumors

Institutions: 1. Department of Cancer Biology, Beckman Research Institute of the City of Hope, 2. Kyushu University, 3. Integrative Genomics Core, Beckman Research Institute of the City of Hope, 4. Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center Team: Mori H1, Saeki K1, Chang G1, Wang J3, Wu X3, Hsu […]

Conversion of Normal Cells to Pro-tumorigenic Lung Cancer Cells Can Occur by the Transfer of Micro RNAs From Circulating Extracellular Vesicles

Institution: Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy Team: Pontis F., Roz L., Mensah M., Segale M., Moro M., Bertolini G., Petraroia I., Centonze G., Ferretti A.M., Sautoni P., Pastorino U., Fortunato, O., and Sozzi, G. Application: In vitro interaction among extracellular vesicles to evaluate their pro-tumorigenic activity Disease Model: Lung Cancer Hydrogel: VitroGel® […]

Glucose Metabolism in Obese Mice can be Improved by Implantation with Photoactivated Adipose Stem Cells

Institution: Southwest Medical University, Luzhou, Sichuan, China Team: Zhu L., Feng Z., Shu X., Gao Q., Wu J., Du Z., Li R., Wang L., Chen N., Li Y., Luo M., and Wu J. Application: In vivo implantation of adipose stem cells to ameliorate glucose intolerance in obese mice Disease Model: Type 2 Diabetes Hydrogel: VitroGel® […]