Manipulation of the adenosine metabolite ADK-L may offer a way to modulate cell invasion and proliferation of breast cancer cells, offering a possible therapeutic solution to aggressive breast cancers. Institution: Legacy Research Institute, Mid-Columbia Medical Center Team: Bahar Shamloo*, Nandita Kumar, Randall H. Owen, Jesica Reemmer, John Ost, R. Serene Perkins, and Hai-Ying Shen* Application: […]
Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Institution: Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto di scienze e tecnologie Molecolari CNR Team: Cristina Borzi, Linda Calzolari, Anna M. Ferretti, Laura Caleca, Ugo Pastorino, […]
Introducing OSA 1777, a cell line derived from recurring osteosarcoma, which unlike existing cell lines, forms spheroids in 3D culture reminiscent of osteosarcoma tumors. Institution: David Geffen School of Medicine, University of California, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Chinese Academy of Medical Sciences and Peking Union Medical College Team: Pichaya […]
New mechanistic insights into the tumorigenesis of DIPG yield a novel potential treatment: PPM1D inhibitors Institution: Emory School of Medicine Team: Mwangala Precious Akamandisa, Kai Nie, Rita Nahta, Dolores Hambardzumyan, and Robert Craig Castellino * Application: Use of VitroGel 3D for in vivo studies and assessing cell survival Disease model: Diffuse intrinsic pontine glioma (DIPG) […]
Three-dimensional hydrogels help to unravel the role and mechanism of action of BST-2 in breast cancer growth and metastasis and introduce a putative new therapy Institution: Carver College of Medicine, University of Iowa, Stony Brook University, Stanford University School of Medicine Team: Wadi D. Mahauad-Fernandez, Chioma M. Okeoma * Application: 3D tissue model to evaluate […]
Repressing CDK9 blocks cell spheroid formation in 3D culture and delays growth of synovial sarcoma cells Institution: Carver College of Medicine, University of Iowa, Stony Brook University, Stanford University School of Medicine, Atta-ur-Rahman School of Applied Bio sciences, National University of Sciences and Technology Team: Wadi D. Mahauad-Fernandez, Wasifa Naushad, Tyler D. Panzner, Amani Bashir, […]
The biocompatible and injectable VitroGel hydrogel culture system enhances pulp-dentin regeneration and has the potential for chair-side regenerative endodontic procedures Institution: The Fourth Military Medical University, China Medical University Team: Min Xiao, Jun Qiu, Rong Kuang, Beidi Zhang, Wei Wang*, Qing Yu * Application: In vivo utilization to study biocompatibility and differentiation potential of primary […]
Three-dimensional cancer-derived organoids introduce TrkA as a promising new biomarker and target for a nearly incurable disease. Institution: University of Campania Team: Marzia Di Donato, Gustavo Cernera, Antimo Migliaccio*and Gabriella Castoria * Application: 3D tissue model to evaluate role of a gene in tumor progression Disease model: Prostate cancer Cell types: Human PC-derived DU145 cells […]
