Category Archives: Research Highlights

Breaking the (cell) cycle: Introducing CDK9 as a prognostic biomarker and therapeutic target in synovial sarcomas

Repressing CDK9 blocks cell spheroid formation in 3D culture and delays growth of synovial sarcoma cells Institution: Carver College of Medicine, University of Iowa, Stony Brook University, Stanford University School of Medicine, Atta-ur-Rahman School of Applied Bio sciences, National University of Sciences and Technology Team: Wadi D.  Mahauad-Fernandez, Wasifa Naushad, Tyler D.  Panzner, Amani Bashir, […]

Getting to the root of the problem: Injectable VitroGel® 3D hydrogel scaffolds enhance odontogenic differentiation in vivo

The biocompatible and injectable VitroGel hydrogel culture system enhances pulp-dentin regeneration and has the potential for chair-side regenerative endodontic procedures Institution: The Fourth Military Medical University, China Medical University Team: Min Xiao, Jun Qiu, Rong Kuang, Beidi Zhang, Wei Wang*, Qing Yu * Application: In vivo utilization to study biocompatibility and differentiation potential of primary […]

Trk-ing down castration-resistant prostate cancer: 3D organoid models reveal a new drug target for an aggressive form of prostate cancer.

Three-dimensional cancer-derived organoids introduce TrkA as a promising new biomarker and target for a nearly incurable disease. Institution: University of Campania Team: Marzia Di Donato, Gustavo Cernera, Antimo Migliaccio*and Gabriella Castoria * Application: 3D tissue model to evaluate role of a gene in tumor progression Disease model: Prostate cancer Cell types: Human PC-derived DU145 cells […]